{"id":2449,"date":"2026-05-30T11:49:17","date_gmt":"2026-05-30T09:49:17","guid":{"rendered":"https:\/\/nanosmartlab.cnr.it\/?p=2449"},"modified":"2026-05-30T11:49:34","modified_gmt":"2026-05-30T09:49:34","slug":"stick-and-sense-the-new-flexible-paper-based-sers-sensor-for-ultra-sensitive-pathogen-detection-new-article-%f0%9f%93%84%f0%9f%a7%ab%f0%9f%a6%a0","status":"publish","type":"post","link":"https:\/\/nanosmartlab.cnr.it\/?p=2449","title":{"rendered":"&#8220;Stick-and-Sense&#8221;: The New Flexible Paper-Based SERS Sensor for Ultra-Sensitive Pathogen Detection &#8211; New Article \ud83d\udcc4\ud83e\uddeb\ud83e\udda0"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large animated heartBeat\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"653\" src=\"https:\/\/nanosmartlab.cnr.it\/wp-content\/uploads\/2026\/05\/Captura-de-pantalla-2026-05-30-a-las-11.45.22-1024x653.png\" alt=\"\" class=\"wp-image-2450\" srcset=\"https:\/\/nanosmartlab.cnr.it\/wp-content\/uploads\/2026\/05\/Captura-de-pantalla-2026-05-30-a-las-11.45.22-1024x653.png 1024w, https:\/\/nanosmartlab.cnr.it\/wp-content\/uploads\/2026\/05\/Captura-de-pantalla-2026-05-30-a-las-11.45.22-300x191.png 300w, https:\/\/nanosmartlab.cnr.it\/wp-content\/uploads\/2026\/05\/Captura-de-pantalla-2026-05-30-a-las-11.45.22-768x490.png 768w, https:\/\/nanosmartlab.cnr.it\/wp-content\/uploads\/2026\/05\/Captura-de-pantalla-2026-05-30-a-las-11.45.22.png 1420w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ensuring the safety of our food and drinking water remains a critical challenge for global public health<sup><\/sup><sup><\/sup>. Traditional methods to identify waterborne and foodborne pathogens\u2014such as <em>Escherichia coli<\/em>\u2014are reliable but notoriously slow, expensive, and tied to specialized laboratory infrastructures<sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup>. To bridge this gap, a multidisciplinary research team has developed an innovative, low-cost solution: a flexible &#8220;Stick-and-Sense&#8221; paper tape sensor that brings high-sensitivity laboratory testing directly into the field<sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Published in the prestigious journal <em>Food Chemistry<\/em>, the study introduces a Surface-Enhanced Raman Scattering (SERS) biosensor created by coating standard commercial masking tape with a self-assembled monolayer of gold nanoparticles (Au NPs)<sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Dual-Mode Capability: Water and Complex Food Matrices<\/strong> The true power of this platform lies in its versatile dual-mode detection strategy<sup><\/sup><sup><\/sup><sup><\/sup>:<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>Label-Free in Water:<\/strong> When deployed in aqueous environments, the sensor identifies and discriminates among different bacterial strains (such as <em>E. coli<\/em>, <em>Enterococcus<\/em>, and <em>Citrobacter<\/em>) based solely on their unique molecular Raman fingerprints combined with Principal Component Analysis (PCA). In this mode, it achieves a remarkable detection limit of just 26 CFU\/mL.<\/li>\n\n\n\n<li><strong>Targeted Immunodetection in Food:<\/strong> Complex matrices like milk present major background interference for standard sensors. To solve this, the substrate was functionalized with specific anti-<em>E. coli<\/em> antibodies. This allows the sensor to capture and isolate the target pathogen directly from commercial milk, achieving an experimental limit of detection as low as 25 CFU\/mL.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>High Performance at an Accessible Cost<\/strong> Thanks to the natural porosity of the paper support, the gold nanoparticles organize into a tight three-dimensional network of plasmonic &#8220;hot spots&#8221;. This arrangement grants the substrate an extraordinary electromagnetic enhancement factor of approximately 10^7 , putting its performance on par with fragile, expensive rigid substrates like silicon or glass.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, a preliminary economic evaluation highlights the high commercial viability of the device, with a material cost estimated at just around \u20ac0.19 per fully functionalized sensor<sup><\/sup>. This combination of flexibility, high sensitivity, and extreme affordability marks a major milestone toward immediate, on-site food safety and environmental screening<sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acknowledgments: This groundbreaking research was carried out under the brilliant guidance of Dr. Lucia Petti and her outstanding team at the Institute of Applied Sciences and Intelligent Systems &#8220;Eduardo Caianiello&#8221; (ISASI &#8211; CNR) in Pozzuoli<sup><\/sup><sup><\/sup><sup><\/sup><sup><\/sup>. We extend our deepest gratitude to the group for their continuous effort in translating advanced nanotechnology into real-world diagnostics<sup><\/sup><sup><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-colibri-color-1-color\">Discover Our Article:<\/mark><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2026.149599\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.foodchem.2026.149599<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ensuring the safety of our food and drinking water remains a critical challenge [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":2450,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[13,11],"tags":[51,49,35,47,34,50,23,53,52],"class_list":["post-2449","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-article","category-news","tag-biosensors","tag-foodsafety","tag-innovation","tag-isasicnr","tag-nanotechnology","tag-publichealth","tag-sers","tag-smartmaterials","tag-waterquality"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>&quot;Stick-and-Sense&quot;: The New Flexible Paper-Based SERS Sensor for Ultra-Sensitive Pathogen Detection - New Article \ud83d\udcc4\ud83e\uddeb\ud83e\udda0 - Nano Smart Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nanosmartlab.cnr.it\/?p=2449\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;Stick-and-Sense&quot;: The New Flexible Paper-Based SERS Sensor for Ultra-Sensitive Pathogen Detection - New Article \ud83d\udcc4\ud83e\uddeb\ud83e\udda0 - Nano Smart Lab\" \/>\n<meta property=\"og:description\" content=\"Ensuring the safety of our food and drinking water remains a critical challenge [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nanosmartlab.cnr.it\/?p=2449\" \/>\n<meta property=\"og:site_name\" content=\"Nano Smart Lab\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-30T09:49:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-30T09:49:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nanosmartlab.cnr.it\/wp-content\/uploads\/2026\/05\/Captura-de-pantalla-2026-05-30-a-las-11.45.22.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1420\" \/>\n\t<meta property=\"og:image:height\" content=\"906\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"BRYAN GUILCAPI\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"BRYAN GUILCAPI\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nanosmartlab.cnr.it\\\/?p=2449#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nanosmartlab.cnr.it\\\/?p=2449\"},\"author\":{\"name\":\"BRYAN GUILCAPI\",\"@id\":\"https:\\\/\\\/nanosmartlab.cnr.it\\\/#\\\/schema\\\/person\\\/2ba791033fbe2b9de35d44edb4401274\"},\"headline\":\"&#8220;Stick-and-Sense&#8221;: The New Flexible Paper-Based SERS Sensor for Ultra-Sensitive Pathogen Detection &#8211; 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